the balance of hydroxychloroquine?

THE ESSENTIAL

  • First, hydroxychloroquine is a preventative and/or curative treatment for malaria.
  • As of 2020, the French government lifted the derogations that allowed hydroxychloroquine to be prescribed in hospital to treat patients with severe forms of Covid-19.

It is a study french takes stock: more than 16,000 deaths from hydroxychloroquine administered at the beginning of the Covid-19 epidemic in certain hospitals, notably that of Marseille, since Professor Didier Raoult defended this treatment. Since then, its effectiveness in treating the coronavirus has been disputed by much of the scientific community.

16,274 dead in eight countries

Very accurately, researchers from the University of Lyon estimate that the number of deaths from this treatment would be 16,274 in eight countries, including France. To arrive at this result, they analyzed health data of 96,032 patients hospitalized in 671 hospitals in eight countries between December 20, 2019 and April 14, 2020 who tested positive for Covid-19. Among them, only 14,888 people received this type of treatment within 48 hours. The other 81,114 patients who did not receive this treatment were part of a control group.

A higher mortality rate in treated patients

The mortality rate of this control group was 9.3%, much lower than that of the treated patients. In detail : “These rates were 16.4% with chloroquine alone, 22.2% with chloroquine + a macrolide (a kind of antibiotic)18% with hydroxychloroquine alone and 23.8% with hydroxychloroquine + a macrolidewe can read on the website APM News. After adjusting for covariates (age, sex, comorbidities, disease severity, etc.), all treatments were associated with a significantly increased risk of in-hospital death compared to no treatment. This increased risk ranged from 34% to 45% depending on the treatment, with the highest risk observed with the hydroxychloroquine + macrolide combination“.

No exact dates

One of the limitations of this study is the difficulty in collecting accurate data on the use ofHydroxychloroquine at the start of the pandemic. Information not always available and searchable by researchers. “We are not interested in an exact result, we mainly wanted to show what the concrete consequences can be if a potentially toxic drug is prescribed.”explains Professor Jean-Christophe Lega Parisian.

Hydroxychloroquine”could also take chances away from people”

guest of the show C to you on France 5Professor Arnaud Fontanet, researcher at the Pasteur Institute and member of the Scientific Council, declined to comment on the study but said that “The point is that this treatment, which was not effective and we saw that very quickly, causing side effects and a slight excess mortality, may also have deprived people who believed they were protected when they weren’t“A reality since the epidemic began, when patients even went so far as to self-medicate with hydroxychloroquine…

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